Peg-PDlla polymeric nanovesicles loaded with doxorubicin and hematoporphyrin monomethyl ether on human hepatocellular carcinoma hepg2 cells in vitro

نویسندگان

  • guang-hua Xiang
  • Yong Wang
  • Du cheng
  • Jing-Xing Zhou
  • Xin-Tao shuai
چکیده

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php International Journal of Nanomedicine 2013:8 4613–4622 International Journal of Nanomedicine Dovepress

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Effect of PEG-PDLLA polymeric nanovesicles loaded with doxorubicin and hematoporphyrin monomethyl ether on human hepatocellular carcinoma HepG2 cells in vitro

OBJECTIVE To evaluate the cytotoxicity of poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-PDLLA) nanovesicles loaded with doxorubicin (DOX) and the photosensitizer hematoporphyrin monomethyl ether (HMME) on human hepatocellular carcinoma HepG2 cells and to investigate potential apoptotic mechanisms. METHODS PEG-PDLLA nanovesicles were simultaneously loaded with DOX and HMME (PEG-PDLLA-...

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تاریخ انتشار 2013